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Chronic Pain and Inflammation relief
Lymphoma is a cancer in the lymphatic cells of the immune system. one form of lymphoma is Diffuse Large B cell lymphoma (DLBCL)which is the most common type of Non-Hodgkin lymphoma (NHL) and accounts for over 40% of newly-diagnosed cases of NHL in the United States each year.
Chemotherapy is the standard treatment for cancererous B cells but can produced a number of unwanted side affects in the intestines, causing vomiting and nausea. Recent research at the University of California in San Diego, headed by Dr Irene Pedersen discovered a link between DLBCL and inflammation and they published the result in EMBO Molecular Medicine.
A key factor that promotes inflammation is a protein called TNFa. When the researchers gave DLBCL cells TNFa, their levels of miR155 went up while SHIP protein levels went down. In contrast, when TNFa was blocked, SHIP expression increased and the growth of the tumour cells slowed down.
The researchers didn't stop with cells in a dish,they also wanted to see if blocking TNFa would result in slower tumour growth. Indeed, they found that mice treated with TNFa blocking antibodies showed reduced growth of DLBCL tumours.
Taken together, Dr. Pedersen and colleagues showed that reducing inflammation is an effective way to help fight DLBCL. The implications of this work give clinicians yet another tool in their arsenal of weapons against lymphoma, and possibly other types of cancer.
David Ogden
CEO TheInterbiz LLC
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