Fights inflammation to free you from pain
A high intake of fruits and vegetables was found to be positively associated with a lower chance of many diseases in epidemiological studies and clinical trials linked to the every day damage caused by free radicals. The free radicals are constantly formed as byproducts of aerobic metabolism in the human body (Davies, K. J. A). These are molecules or atoms with unpaired electrons; they are generally reactive oxygen or nitrogen species (ROS or RNS). The most common are superoxide, peroxyl radical, nitric oxide (NO), and peroxynitrite (ONOO-).
These free radicals have been associated with many chronic and degenerative diseases including, inflammatory disease, vascular diseases, diabetes, cancer, and overall aging.
The body has developed a number of mechanisms to minimize free radical damage and even repair damage. Enzymes such as superoxide dismutase, catalase, and glutathione reductase, as well as antioxidants such as vitamin A, vitamin C, vitamin E, and polyphenols play important roles in protecting the body from free radical damage. Superoxide dismutase (SOD) is present in both the mitochondria and the cytosol. Hydrogen peroxide can be easily transformed into the dangerous hydroxyl radical via reaction with Fe2+. Catalase reacts with hydrogen peroxide to form water and oxygen. Glutathione peroxidase can also react with hydrogen peroxide, by reducing hydrogen peroxide and oxidizing glutathione but all these physiological protective mechanisms are still not protecting has from developing disease.
Dietary antioxidants are believed to be good external sources for protection, working in synergism with the free radical defence mechanism along with the enzymatic processes in the body.
Nitric oxide (NO) is an inorganic free radical that functions as an intracellular messenger and effector molecule. It is produced during the conversion of arginine to citrulline and its production is catalyzed by the enzyme nitric oxide synthase (NOS) (Knowles, R. G).
NOS has three isoforms: NOS I, II, and III. Out of these three isoforms, only NOS II is inducible and is produced during macrophage activation. Macrophage activation is thus accompanied by the induction of inducible nitric oxide synthase and sustained release of NO (MacMicking)
Synthesis of NO endows macrophages with cytostatic or cytotoxic activity against viruses, bacteria, fungi, and tumour cells (Nathan, Hibbs) thus decreasing inflammation.
During the inflammatory process a chemical is released known as myeloperoxidase (MPE). This is the most powerful oxidant produced by the human neutrophil during acute inflammation, especially from infection or cancer. Betalains found in the Nopal cactus fruit extinguish the fire of inflammation caused by MPE and protect the healthy cells. Betalains rescue the cell by quenching the fire of free radicals.
There are times when the body cannot heal itself. If Inflammation overwhelms a cell it may be damaged beyond repair. Damaged, dead cells must be removed or they will become the focus of infection and illness. Betalains assist macrophage to engulf the dead cell and eliminate it from your body. Then, toxins are drained away from the cell and the protein matrix of Betalains permeates and reinforces the cell, returning it to health. In addition, Betalains drain toxic waste water surrounding the cells and create a cooling environment conducive to cell health.
It is estimated that 27 million Americans age 25 and older have inflammatory diseases like rheumatoid arthritis and osteoarthritis. Although osteoarthritis is more common in older people, younger people can develop it usually as the result of a joint injury, a joint malformation, or a genetic defect in joint cartilage. Both men and women have the disease. Before age 45, more men than women have osteoarthritis; after age 45, it is more common in women. It is also more likely to occur in people who are overweight and in those with jobs that stress particular joints. As the population ages, the number of people with osteoarthritis will increase and by 2030, about 20 percent of Americans – about 72 million people will have passed their 65th birthday and will be at high risk for the disease.
Osteoarthritis, sometimes called degenerative joint disease, is the most common form of arthritis. Osteoarthritis occurs when cartilage in your joints wears down over time. Osteoarthritis can affect any joint in the body, though it most commonly affects joints in the hands, hips, knees and spine. Osteoarthritis typically affects just one joint, though in some cases, such as with finger arthritis, several joints can be affected. Osteoarthritis gradually worsens with time, and no cure exists. But osteoarthritis treatments can relieve pain and help you remain active. Taking steps to actively manage your osteoarthritis may help the individual gain control over osteoarthritis pain. (American Cancer Society, 2008)
Rheumatoid arthritis (RA) is a chronic systemic disease of unknown origin that predominantly involves synovial tissue. RA affects 1.3 million Americans or 0.5%–1.0% of the global population, with females affected more frequently than males.
Rheumatoid arthritis is a serious disease and prevention and early diagnosis are the best treatment in order to prevent severe deformity and joint erosion. The etiology of RA is unknown but seems to be multifactorial. There is a certain genetic susceptibility, and studies in twins indicate a concordance of about 15%–20%. Environmental factors (smoking) or infectious agents are suggested to play a role in the etiology, but their contribution has yet to be defined (Oliver J. Sommer, 2003).
David Ogden
CEO TheInterbiz LLC
Independent TriVita Affiliate 13142173
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