Cactus Juice Chronic Inflammation and Pain Relief

Original Article @ David Ogdens Blog

Nopalea Cactus Juice
Natural Pain and Inflammation Relief

Inflammation is the latest buzz word, popping up everywhere in the world of nutrition and health. Why eat an anti-inflammatory diet? What's food got to do with it? Let's begin with the typical definition of inflammation: acute inflammation is a cascade of metabolic immune system reactions in response to harmful stimuli. In other words, something causes harm to bodily tissues. It could be a specific trauma like a cut, or it could be viruses, bacteria, or chemicals that become too numerous. The signs you might notice are pain, heat, redness, swelling, and loss of function. You feel the heat because blood flow begins to increase in the site of inflammation, fluids build up and this pushes on nerve endings causing pain. There are some cells the immune system sends to the site that will try to eat the bad stuff, while other cells are like soldiers sent in with guns that shoot chemicals to kill the bad guys. If it is not resolved, you lose function… If resolved properly, the ca scade stops and goes back to normal, and healing results.

Inflammation is meant to protect and initiate healing in the tissues. That is the kind of inflammation we are most familiar with. There is also chronic inflammation, or unresolved and continuous low grade inflammation. The continuous cascade of immune reactions never stops, and can actually cause the body to begin attacking itself, as in all autoimmune disorders. This kind of inflammation is also responsible for most chronic degenerative conditions like cancer, heart disease, diabetes I and II, psoriasis, fibromyalgia, and more.

The conditions on the top of list, cancer, heart disease, and diabetes are poised to break our health care system in unbearable amounts of cost in treatments. And for the most part, they are preventable with proper lifestyle habits! You can see problems in our health care system happening right now if you look closely… Insurance is so expensive, hardly anyone can actually afford to be covered. Then when you are covered by some detailed and fancy sounding, outrageously expensive policy, they don't actually want to pay for anything. They will catch you on little details, make you pay part of the cost, or decide to not pay at all.

Managing and reversing inflammation on your own, through natural means is far less expensive than getting hooked to pharmaceuticals, that appear to help, as you continually climb to the next rung on the disease ladder and add more drugs to manage more symptoms as time goes by. Starting with square one; your diet, can be the most socially responsible and personally empowering thing you do.

What do foods have to do with inflammation? Food sensitivities, undigested foods, dead dried up, chemically laden processed, over heated poor food-like substances can cause the cascade of inflammation to rip through your system; stemming from various causes like leaky gut, not enough stomach acid, compromised liver, gall bladder, pancreas, or the foods are simply rejected by your immune system. Everyday, the wrong foods add to inflammation, stir up old inflammation, continue the cycle of inflammation over and over until your body can't stop the runaway train that becomes a chronic condition.

Can you reverse it? Yes and, how much function you can recover depends on the damage done. The body has an beautiful and innate ability to heal on it's own under the right conditions. Eating an anti-inflammatory diet puts your immune system at ease and helps to allow the body to begin the healing process. If your immune system is continuously firing off in inflammatory cascades, it has less ammunition to contribute to fighting colds, flu, respiratory infections, stomach bugs and so on. You may notice that you get sick more often and more severely. How often are you home sick? How often do you find yourself needing those antibiotics? Am anti-inflammatory diet also means immune boosting because the immune system can finally work on other things.

David Ogden
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Cactus Juice Chronic Inflammation and Pain Relief

Original Article @ David Ogdens Blog

Nopalea Cactus Juice
Natural Pain and Inflammation Relief

I do not know of anyone who does not want to look younger, feel younger and live longer, now its seems that reducing inflammation in you body can help you achieve these dreams.

I was doing some research on inflammation and came across an article by the world renowned Dr. Perricone, who stated that the single cause of aging and age related diseases and conditions such as diabetes, Alzheimer, arthritis, heart disease, diabetes, wrinkled skin and loss or bone and muscle is inflammation.

The WebMD site for example has has information about inflammation and aging written by Susan Moore R.D. spokeswoman for the American Dietetic Association saying that food choices are critical in delaying the onset of aging, and the sooner you start the better. Foods that are high in phytonutrients are the key, because as we age we become more effected to the long term effects of oxidative stress( where body has too many free radicals and inflammation on the cellular level).

There are many ways of lowering inflammation, some simple and some more profound. changing your diet is the first one, giving up high glycemic foods, such as cakes, cookies, muffins, breads, soda's etc.

Taking Nopalea cactus juice which is rich in bioflavonoids, the photonutrients that help to reduce inflammation is another. Nopalea is best known for it role in fighting pain and inflammation, but it can also provide other benefits making you feel better, look better,live longer, sleep better and have more energy.

David Ogden
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Cactus Juice Chronic Inflammation and Pain Relief

Original Article @ David Ogdens Blog

Nopalea Cactus Juice
Natural Pain and Inflammation Relief

Chronic Depression can cause brain damage, it seems once again inflammation, a natural function of the the body is once again to be blamed according to a report that that was published a couple of years ago, at the university of California.

"It's necessary and normal so that an individual can adapt, change behaviour and deal with altered circumstances," Markou said. Real problems occur only "when these restructuring processes go into overdrive, beyond what is necessary and adaptive, and for longer periods of time than needed. Then depression becomes pathological."

Markou and Wager-Smith, the researchers involved, argued that existing, conflicting views about depression actually describe different aspects of the same phenomenon. Psychoanalytic and sociological theories refer to the psychological transformation that occurs during a productive depressive episode. Biomedical theories relate to the neural remodeling that underlies this psychological change. And neurodegenerative theories account for remodeling malfunctions.

"The big question, of course, is why aren't all people affected the same way," said Markou. "Why do some people deal effectively with stress, but others perpetuate a pathological state? This is an interesting question for future research."

The researchers' findings may have clinical ramifications as well. If psychological and physical pain responses share similar biological mechanisms, then analgesic agents could be useful in treating at least some symptoms of depression. Similarly, if chronic depression is proven to be a neuroinflammatory condition, then anti-inflammatory treatments should also have some antidepressant effects.

So my question today is could cactus juice which fight chronic pain and inflammation also reduce depression. A quick search on the Internet revealed one article of support.

"However, one day I went along to a women's networking event and met a woman who told me about Aloe Vera. She told me that you could drink this 'wacky cactus juice' and that it might help me with the migraines. At that time I was tired, fed up and would have tried anything. Well, within three weeks the Aloe Vera Gel sorted out my digestion, and after 3 months the migraines were showing definite signs of improvement. 6 months later the incidence and severity were reduced by 90%"

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Cactus Juice Chronic Inflammation and Pain Relief

Original Article @ David Ogdens Blog

Nopalea Cactus Juice
Natural Pain and Inflammation Relief

I have been writing chronic inflammation for some time now and came across an article about grounding which may be of interest. Grounding or earthling, in the simplest terms possible, can be a simple as walking barefoot; grounding your body to the Earth. Your skin in general is a very good conductor, so you can connect any part of your skin to the Earth, but if you compare various parts there is one that is especially potent, and that's right in the middle of the ball of your foot; a point known to acupuncturists as Kidney 1 (K1). It's a well-known point that conductive connects to all of the acupuncture meridians and essentially connects to every nook and cranny of your body.

When you're grounded there's a transfer of free electrons from the Earth into your body. And these free electrons are probably the most potent antioxidants known to man. These antioxidants are responsible for the clinical observations from grounding experiments, such as beneficial changes in heart rate, decreased skin resistance, and decreased levels of chronic inflammation.

Furthermore, researchers have also discovered that grounding thins your blood, making it less viscous. This discovery can have a profound impact on cardiovascular disease, which is now the number one killer in the world. Virtually every aspect of cardiovascular disease has been correlated with elevated blood viscosity. It turns out that when you ground to the earth, your zeta potential quickly rises, which means your red blood cells have more charge on their surface, which forces them apart from each other.

This action causes your blood to thin and flow easier. It also causes your blood pressure to drop. By repelling each other, your red blood cells are also less inclined to stick together and form a clot. Additionally, if your zeta potential is high, which grounding can facilitate, you not only decrease your heart disease risk but also your risk of multi-infarct dementias, where you start losing brain tissue due to micro-clotting in your brain.

I do sometimes walk about barefoot and I admit it a great feeling but I did not realise that it was good for you perhaps I will be doing it more often in the future.

David Ogden
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Arthritus and Inflammation

Original Article @ David Ogdens Blog

Nopalea Cactus Juice
Natural Pain and Inflammation Relief

A common perception exists that arthritis can't be prevented because the joint cartilage (the cushioning that covers the bones in a joint) simply wears away with age. But actually joint cartilage wears away with inflammation with is a normal healing process. But if the inflammatory response does not shut off and becomes chronic, it can not only affect joints, but blood vessel walls (atherosclerosis), lining cells of the gut (as in lactose and gluten intolerance), and contribute to diseases like diabetes, cancer, strokes and other illnesses.

If you can prevent chronic inflammationn you can prevent joint problems. Even if you already have arthritis reducing the amount of inflammation in your system will help relieve your symptoms and give you more freedom of movement – sometimes within weeks or days. Highly movable joints such as the wrists, fingers, shoulders, hips, and knees, are the most likely to be affected by osteoarthritis. These are called "synovial joints" because the two bones meeting in this type of joint are bathed in synovial, a clear fluid whose job is to provide lubrication. Sometimes, though, the membrane that secretes the synovial becomes inflamed. According to Dr. Vijaya Nair in her book Prevent Cancer, Strokes, Heart Attacks and other Deadly Killers,

"When an avalanche of inflammatory chemicals gets released, those inflammatory chemicals wear away joint cartilage. The first step in any program to combat arthritis and joint problems isn't to stop the pain – it's to s top the inflammation."

Doctors can prescribe anti-inflammatory drugs, but there are healthier ways to combat inflammation. People can alter their diet to include foods such as olive oil, cod, salmon, sardines, kale, ginger, book choy, mushrooms, avocados, cranberries, apples, cinnamon, almonds just to name a few. Avoiding sugar, processed foods, polyunsaturated oils that contain few omega-3's, and for some people, gluten and diary. Hormone-laden meat can also trigger an inflammatory response as can pesticides and chemical ingredients in foodstuffs. Stress is probably the biggest factor because the chemical reaction our bodies create to stressors lowers our immune response and allows inflammation to run unchecked.

In addition Dr. Nair recommends a simple list of supplements that she has seen create an effective treatment. Probably the easiest, most effective anti-inflammatory supplement is curcumin. But be careful because not all curcumin is effective. You need one that has Curcumin, Demethoxycurcumin and Bisdemethoxycurcumin – collectively known as Curcuminoids. Other ingredients that help inflammation are bromelain, resveratrol, ginger, alpha lipoic acid and zinc and cactus juice. It is also prudent to take a good plant oil combination made from flax, primrose and sunflower oils.

David Ogden
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Nopal Cactus Juice

Original Article @ David Ogdens Blog

Nopalea Cactus Juice
Natural Pain and Inflammation Relief

Each day brings a new wave of toxins, pollutants, bacteria, viruses and chemicals into your body — from the air you breathe and the food you eat, to the water you drink and even the things you touch. Stress, nutrient deficiencies, metabolic waste and physical injury also take their toll on your health.

What is your bodies reaction to these invaders ... Inflammation, which is your bodies natural defence meachanism. However in some cased this can develop into chronic inflammtion, which is dangerous.

In 2004, TIME magazine ran an astonishing story about inflammation and its destructive effect on the body's health.
Since then, medical science went on to find even more links between chronic inflammation and highly debilitating conditions, including:

• Muscles, joint and bone inflammation – causing ongoing body pain
• Respiratory inflammation – causing allergic reactions
• Digestive tract inflammation – causing bloating, cramps and burning
• Widespread body cell inflammation – causing overall tiredness

Inflammation is the problem… Nopalea cactus juice is a solution!

Nopalea (No--pah la-y'uh) helps fight off harmful toxins surrounding your body's cells. So, it helps your body reduce inflammation and promote optimal cellular health. When your cells are healthy and free of toxins, your whole body can function at its best.

Nopalea cactus juice is a tasty wellness drink sourced from the fruit of the Nopal cactus. The healing properties of the Nopal cactus have been relied on for centuries by native peoples, and they're now available in Nopalea. Each 32–ounce bottle of Nopalea brims with the health benefits of the Nopal fruit, in a proprietary blend delivering the rare, potent Bioflavonoid antioxidants.

Bioflavonoids: not your typical antioxidants
Bioflavonoids are powerful antioxidants that help your body reduce inflammation. Bioflavonoids support the structure and function of cells. They also work to neutralize toxins by supporting your natural detoxification processes as well as draining away accumulations of toxic waste.

The average U.S. or Canadian diet is typically devoid of Bioflavonoids. The main reason for this is that Bioflavonoids are only available from a few types of plants: the Nopal cactus, beets, Swiss chard and a few weeds and fungi. But not all Bioflavonoid-producing plants are equal. Plants produce Bioflavonoids to protect themselves from harsh environments; so the harsher the environment, the greater the Bioflavonoid production. That's why, among all of the world's plants, the Nopal cactus has the highest concentration of Bioflavonoids – it lives in the brutally inhospitable conditions of the Sonoran Desert in SW USA and Mexico.

David Ogden
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Cactus Juice Chronic Inflammation and Pain Relief

Original Article @ David Ogdens Blog

Nopalea Cactus Juice
Natural Pain and Inflammation Relief

Some people can tolerate pain and others can't however pain is a signal from your body that something is wrong, so you should not always ignore it, especial if it continues for a few days.

What is the difference between acute pain and chronic pain?

There is an old saying that applied to pain and many other areas of life including work, play and relationships: "If the stove is too hot, take your hand off of it!" We take our hand off of a literal hot stove because of what is called a withdrawal reflex. We will often withdraw our hand or foot from a painful experience even before we have fully defined what is hurting us. In acute (short-term) pain, removing the trigger is very important. Common triggers for acute pain are:

• Trauma
• Toxins
• Deficiencies
• Stress

On the other hand some pain persists even when you "take your hand off the stove". This is called chronic (long-term) pain. For instance, chronic back pain and chronic headaches persist long after the trauma that caused them. Many times there is no specific trauma. The pain just starts and won't go away.

This happens because of the way our nerves are constructed. You see, nerves don't really feel pain; they merely sense stimulation. It is up to our brain to interpret the signal as pain. We have specific nerve fibers that "fire" under specific conditions. One group of fibres may be triggered by a sharp jab, another group by dull pressure. One group may be triggered by heat and another by extreme cold. The nerves carry this specific message to our brain for interpretation. Our brain interprets the signal as painful. The volume of the signal helps us determine the intensity of the pain.

In chronic pain the signal travels from the nerve to the spine and onwards to the brain, the return signal message is supposed to shut off the pain signal when the irritation is gone,but in chronic pain, the return signal is not switched off. Instead, it is amplified.

There are many methods of reducing pain and inflammation, including natural remedies such as nopalea cactus juice, omega 3 and omega 6 fatty acids which unlike prescription drugs have no side effects.

David Ogden
CEO TheInterbiz LLC
1-386-308-1956 (24 hours)
trivita [@] theinterbiz.com
Office Hours-6AM-12AM GMT +8

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Cactus Juice Chronic Inflammation and Pain Relief

Original Article @ David Ogdens Blog

Nopalea Cactus Juice
Natural Pain and Inflammation Relief

Many puzzles are yet to be solved by modern medicine. As we continue to seek causes and solutions for the ills that plague mankind, confusion still swirls around two of the more "mysterious" ailments: chronic fatigue syndrome (CFS) and fibromyalgia (FMS). They have some important traits in common:

• We don't know what causes either CFS or fibromyalgia
• They share several symptoms such as chronic inflammation
• There is no cure

The confusion around these two syndromes is fed by their overlapping nature: It's estimated that up to 70% of people diagnosed with CFS also fit the clinical guidelines for FMS, and vice versa. Most people with CFS have some kind of pain or chronic inflammation, which is a major symptom of FMS. And most people with FMS report fatigue, a major symptom of CFS. No wonder even doctors can be unsure which is which.

We do know, however, that many physicians and researchers (along with patients) support supplementation — including Vitamin B-12 and folic acid — as an important part of managing symptoms. Here's a thumbnail look that helps explain why:

CFS: As the name suggests, this is a disorder that causes extreme fatigue. This fatigue is not the tiredness that goes away after you rest. Instead, it lasts a long time and limits your ability to do ordinary daily activities. Symptoms of CFS include fatigue for six months or more, and other problems such as muscle pain, memory problems, headaches, pain in multiple joints, sleep problems, sore throat and tender lymph nodes. It is most common in women in their 40s and 50s, but anyone can have it. It can last for years.

FMS: Fibromyalgia makes you feel tired and causes muscle pain and "tender points". Tender points are places on the neck, shoulders, back,hips, arms or legs that hurt when touched. Other symptoms can include chronic inflammation trouble sleeping, morning stiffness, headaches, and problems with thinking and memory, sometimes called "fibro fog".

No one knows what causes fibromyalgia. Anyone can get it, but it is most common in middle-aged women. People with rheumatoid arthritis and other autoimmune diseases are especially prone to fibromyalgia.

… both syndromes can affect mental function… this may be a key to the use of B vitamins.

Notice that both syndromes can affect mental function: memory and thinking problems can arise, and this may be a key to the use of B vitamins. As you may know, the medical links between B vitamins and brain function are strong and well documented.

So, it isn't surprising that healthcare professionals in both traditional and alternative medicine, including experts in CFS and FMS, support the use of B vitamins and folic acid to help manage symptoms.

If you or a loved one have, or suspect you have, one of these confusing syndromes, it's important to know that both are much more than just being tired, or having some muscle pain. CFS and FMS are often misunderstood, and deserve attention and treatment. I urge you to consult with your healthcare professional, and to see how the highest quality B vitamin supplementation might help.

David Ogden
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1-386-308-1956 (24 hours)
trivita [@] theinterbiz.com
Office Hours-6AM-12AM GMT +8

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Cactus Juice Chronic Inflammation and Pain Relief

Original Article @ David Ogdens Blog

Nopalea Cactus Juice
Natural Pain and Inflammation Relief

How chronic inflammation worsens your health over time

Though you may not see or even feel chronic inflammation, it could be silently causing trouble within your body right now. Over time, it can result in two kinds of damage: first to the immediate area of your body that's chronically inflamed; and second to your overall health as well. Common problems can include:

• Heart Problems – chronic inflammation is believed to contribute to the formation of plaque in blood vessels, as well as the formation of blood clots. When these blood clots break free into the blood, they can block blood flow to the brain or heart, resulting in a heart attack or stroke.
• Brain Problems – chronic inflammation plays a role in Alzheimer's disease, yet scientists are still uncertain what that role is. However, one theory is that inflammation kicks into gear because of the plaques and tangles in the brains of Alzheimer's patients. In trying to solve the problem, inflammation just makes matters worse.
• Joint Problems – chronic inflammation of the joints can result in destroyed ligaments and tendons, damage to joint cartilage and bone and even bone erosion. This leads to pain, deformity and an inability to perform daily tasks – drastically affecting quality of life.
• Mouth and Gum Problems – dental researchers once thought bacterial infections caused gum disease, but now it is thought that some of the more severe symptoms of gum disease are attributable to chronic inflammation. The National Institute of Dental and Craniofacial Research, part of the National Institutes of Health, report that inflammation can even break down bone and connective tissue that keep the teeth in place.
• Emotional Health Problems – chronic inflammation may even play a role in your emotions. Scientists at the University of Illinois (Champaign/Urbana) discovered that an enzyme secreted by the immune system caused inflammation-related, depression-like symptoms in mice. Because inflammation is linked with conditions often accompanied by depression – such as diabetes, cancer and heart disease – researchers expect that this study will provide insight into chronic inflammation's role in depression.
• Cancer Problems – although researchers haven't discovered the exact mechanism of chronic inflammation's role in cancer, they believe it encourages cancer growth. According to the American Cancer Society, inflammation creates just the right conditions for cancer cells to grow and multiply.

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Pain and Inflammation Relief

Original Article @ David Ogdens Blog

Nopalea Cactus Juice
Natural Pain and Inflammation Relief

More than 50 million Americans suffer from chronic pain. Many people find they can gain long-term control over their pain through many alternative methods like heat or cold application, music, relaxation, exercise, meditation, acupuncture and a positive attitude.

"Pain is a chronic condition, just like hypertension or diabetes," Dr. Turk explains. "When you have a chronic condition, you need to do more things for yourself. It's going to last a long time. It's best to help yourself and learn to self-manage and control your pain."

The Options
In addition to traditional pain relievers, nondrug methods of pain relief may help you gain that control. Some techniques, such as imagery and the use of hot and cold relax the muscles, help you sleep, and distract you from symptoms. Others, such as music, movies, and recorded comedy routines, take your mind off your physical complaints, as does losing yourself in a good book.

While some remedies require little expertise or help from others, some may require instruction from a professional. Dr. Ronald Glick is the director of the University of Pittsburgh Pain Evaluation and Treatment Center. Dr. Glick recommends that patients seek advice from a chronic pain specialist who can coordinate all aspects of management, including physical therapies and psychological techniques.

While these pain relief techniques help many people with chronic pain, they are not cures for pain.

Heat and Cold

"The most important thing about heat and cold is that it gives a sense of control,"

Dr. Turk says. "They are things you can do yourself to help relieve the pain, which can immediately reduce the emotional stress."

Direct Application

"Heat and cold can be quite helpful for people with musculoskeletal conditions," says Dr. Turk. "Something as simple as a bag of frozen peas wrapped in a towel can be a useful self-management technique that relieves muscle tension in the back, neck and shoulders."

Most of us are familiar with holding an ice pack on a twisted ankle or lying on a heating pad for a sore back. But hot and cold treatments can be used in other ways. Moist heat, which is often more effective than dry heat, can be applied with a warm towel or a soak in the tub. An elastic bandage can hold an ice pack in place. A small paper cup filled with water and kept in the freezer becomes an excellent tool for localized cold massage, while iced washcloths can cover a larger area.

Muscle Relaxation Exercises
Progressive muscle relaxation is a technique that may be effective for both muscle spasm pain and stress reduction.

"Relaxation skills are useful in reducing muscle tension, and can help reduce frustration and some of the stress,"

says Jennifer Markham, PhD, at the University of Pittsburgh Pain Clinic. Progressive muscle relaxation involves focusing your attention on each muscle group until it feels heavy and relaxed. You usually begin in the feet and gradually progress upward.

Exercise
Although you may not feel like getting off the couch because you hurt so much, exercising within the confines of your physical limitations can decrease pain. Why? The reasons are complex, but one prominent theory is that exercise releases endorphins, which are natural pain relieving chemicals in your brain.

"Exercise is absolutely critical," says Dr. Turk. "The type of exercise will depend on the condition, but as a general rule of thumb, the more active you remain and the more you use your muscles, the better off you're going to be."

A physical therapist can tailor an initial exercise plan based on your capacity to exercise, and then gradually make recommendations for increasing how much you do and for how long. Pain experts recommend pacing activities. Overdoing it on good days can come back to haunt you later. It's fine to cut back on your exercise during a flare-up of your pain, but it's important to resume your exercise routine as soon as you feel better.

Acupuncture
Acupuncture is a form of Chinese Medicine. It involves insertion of very thin needles into the skin at different and very specific points of the body. It has been shown to be effective for treatment of chronic back pain and some forms of pain resulting from nerve damage. It requires several treatments, usually between 2-5 before a response can be seen. Results of acupuncture also largely depend on the skills of the acupuncturist.

Meditation
The benefits of meditation go beyond relaxation response. Studies show that daily meditation may be an excellent tool in fighting chronic pain. There are a variety of different meditation techniques and one should choose a mediation style that is comfortable for him or her. Meditation can be done easily in the privacy of one's home.

Hypnotherapy
Hypnosis has nothing to do with popular images of stage performance. It was first utilized as a therapeutic modality more than 100 years ago. It is a well documented technique that can be useful in chronic pain management. It is done by a trained and licensed therapist. The exact way by which hypnosis works is not fully understood. It induces the state of focused awareness, which is known to alleviate many forms of pain.

David Ogden
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1-386-308-1956 (24 hours)
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Inflammation and Diabetes

Original Article @ David Ogdens Blog

Nopalea Cactus Juice
Natural Pain and Inflammation Relief

A new link between obesity and type 2 diabetes found in mice could open the door to exploring new potential drug treatments for diabetes, University of Michigan Health System research has found. Drugs for type 2 diabetes commonly target insulin, which lowers blood glucose levels. But the U-M study suggests that glucagon – a pancreas-produced hormone that has the opposite effect of insulin by raising blood glucose levels – may also provide a powerful pathway to preventing and treating the increasingly prevalent disease. Findings of the study were published this week ahead of print in Nature Medicine.

"Reducing sugar levels is the biggest goal for people with type 2 diabetes,"

says senior author Liangyou Rui, Ph.D., associate professor in the Department of Molecular and Integrative Physiology at the U-M Medical School.

"We've mostly focused on controlling insulin production and action to treat diabetes but there has been very little study on the opposite hormone glucagon. "Our study shows for the first time that obesity also affects glucagon action and that this hormone also contributes to high glucose levels found in type 2 diabetes."

Authors identified the NIK/NF-B2 pathway, which promotes glucagon responses in obesity. NIK was abnormally activated in mice with dietary or genetic obesity and the inhibition of liver NIK was found to cure diabetes in obese mice.

Insulin resistance – which reduces the body's ability to decrease blood glucose – has been the main hallmark of type 2 diabetes, which is the most common form of diabetes in the United States afflicting millions of Americans.

"There is a common theory that inflammation in liver and fat tissue associated with obesity causes insulin resistance and that leads to the biggest problem for type 2 diabetes: high blood glucose levels,"Rui says. "But blood glucose is also controlled by this other hormone glucagon, which signals to the liver to produce glucose. Inflammation may enhance the ability of glucagon to increase blood sugar. "Obesity is a growing problem worldwide, leading to more cases of type 2 diabetes,"Rui adds. "We hope to offer more data that can help expand options to treat this rampant disease."

David Ogden
CEO TheInterbiz LLC
1-386-308-1956 (24 hours)
trivita [@] theinterbiz.com
Office Hours-6AM-12AM GMT +8

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